Focus on Mast Cell Activation Syndrome (MCAS)

Mast Cell Activation Syndrome: When Your Immune System Misfires

What Is MCAS?

Mast Cell Activation Syndrome (MCAS) is a misunderstood and often overlooked immune condition where mast cells – your body’s frontline defenders – release inflammatory mediators like histamine when they shouldn’t. Instead of protecting you, they trigger symptoms across multiple systems throughout the body. Cleveland Clinic Allergy & Asthma Network

How It Might Feel in Midlife

Symptoms can flare in bursts and impact several systems at once; skin, digestion, mind, heart, lungs, and more. Signs may include:

Flushing, hives, itching, angioedema (swelling)
Abdominal pain, diarrhea, nausea, acid reflux
Brain fog, fatigue, headaches
Low blood pressure, dizziness, heart rate changes, POTS syndrome
Difficulty breathing or anaphylaxis in severe cases Cleveland Clinic Health

Because symptoms often mimic hormonal shifts or menopausal transition, MCAS can fly under the radar, especially in women over 40 who are already juggling midlife symptoms.

Why Mast Cell Activation Syndrome Is Hard to Spot

MCAS can look different in every person; there’s no single test that confirms it. Diagnosis often hinges on clinical history, elevated mediator levels (like serum tryptase), and improvement with mast cell–blocking treatments. AAAAI Verywell Health Allergy.org.au

Types of MCAS can be primary (clonal mast cell changes), secondary (overreaction to triggers), or idiopathic (no clear cause). Physiopedia Verywell Health

How to Support Yourself (If MCAS Is Suspected)

Work with a knowledgeable provider- preferably an allergist or immunologist. We need to rule out other diagnoses and confirm MCAS before moving forward. Cleveland Clinic Allergy.org.au
Identify and avoid triggers—heat, stress, alcohol, certain foods, fragrances, even medications may set off flares. Health SELF
Use stabilizing tools—Antihistamines (H1 + H2), mast cell stabilizers like cromolyn or ketotifen, leukotriene inhibitors, and, in severe cases, corticosteroids. Herbal options like quercetin may also help under supervision. Nubloom offers a specialized supplement blend (Histamine Harmony) featuring quercetin and other ingredients that have may help support Mast Cell Activation Syndrom and healing. BioMed Central Wikipedia+1
Lifestyle adjustments—Reduce inflammation through a gut-healing, low-histamine diet, prioritize stress management, and build immune rhythm through gentle movement and rest.

Healing Through Compassion & Connection

At NuBloom, we know MCAS isn’t your fault and its not something you can control, it’s your body calling for help. We guide you through lab-based clarity, root-cause healing, and lifestyle support to help calm mast cells, balance your metabolism and hormones, and find peace in your own skin. Our board-certified medical team is well versed in MCAS as well as other complicated hormone and autoimmune issues women face as we age.

MCAS may be rare, but your suffering deserves attention, validation, and healing.

If you are ready to get to the root causes and discover what issues, including this one, may be holding you back….book your FREE Bloom Session now! If you’d like more information on our programs and what we offer click here.

References

Cleveland Clinic. What is Mast Cell Activation Syndrome? Cleveland Clinic
Özdemir Ö. Mast Cell Activation Syndrome: Review. PMC
AAAAI on MCAS. AAAAI
Health Resources: Living with Mast Cell Disease. Allergy & Asthma Network
Health.com overview of MCAS symptoms and lifestyle strategies. Health
Verywell Health: MCAS overview and diagnostic challenges. Verywell Health
Self Magazine on MCAS and diagnostic complexity. SELF
Molderings et al. Mast Cell Activation Disease guide. BioMed Central
Wikipedia: Mast cell stabilizers and ketotifen info. Wikipedia+1

This content is for informational and educational purposes only and is not intended to diagnose, treat, or replace professional medical advice. Always consult your healthcare provider before starting any new supplement, medication, or wellness program. NuBloom provides access to licensed medical professionals through individualized programs, but blog content does not establish a provider-patient relationship. Bloom wisely.